Does mercaptopurine affect the liver?

Mercaptopurine can also lead to a distinctive acute, clinically apparent liver injury that usually presents with fatigue and jaundice and a cholestatic or mixed pattern of serum enzyme elevations 1 to 6 months after starting therapy, but sometimes later, particularly following an increase in dose.

What is 6mmp?

The thiopurine drugs, 6-mercaptopurine (6-MP) and its prodrug azathioprine (AZA), remain the mainstay of immunomodulator therapy for IBD and are indicated in steroid-dependent and -refractory patients, as prophylaxis in CD[1-3].

What happens if I take too much mercaptopurine?

If you take too much mercaptopurine If you accidentally take more mercaptopurine than you should you might feel sick, be sick or have diarrhoea. Tell your doctor or go to a hospital straight away. Take the medicine pack with you.

What happens if you take too much mercaptopurine?

What happens if I overdose on Mercaptopurine (Purinethol)? Early symptoms of an overdose may include loss of appetite, nausea, vomiting, or diarrhea. Later symptoms may include fever or flu-like symptoms.

What enzyme is inhibited by 6-mercaptopurine?

6-MP ribonucleotide inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called phosphoribosyl pyrophosphate amidotransferase (PRPP amidotransferase).

Is 6mp cytotoxic?

6-mercaptopurine is an active cytotoxic agent for use only under the direction of physician experienced in the administration of such agents.

What is TPMT deficiency?

Thiopurine S-methyltransferase (TPMT) deficiency is a condition characterized by significantly reduced activity of an enzyme that helps the body process drugs called thiopurines. These drugs, which include 6-thioguanine, 6-mercaptopurine, and azathioprine, inhibit (suppress) the body’s immune system.

Can mercaptopurine cause kidney problems?

While you are using mercaptopurine, your doctor may want you to drink extra fluids so that you will pass more urine. This will help prevent kidney problems and keep your kidneys working well. Tell your doctor if you are using this medicine together with allopurinol.

Is 6-MP an immunosuppressant?

Both Azathioprine and 6-Mercaptopurine (6-MP) belong to a group of drugs called thiopurines which are immunosuppressants. Thiopurines work by suppressing inflammation and slowing down the body’s immune response. They are also used to avoid rejection following organ transplantation.

Is 6-mercaptopurine the same as mercaptopurine?

Mercaptopurine (6-MP), sold under the brand name Purinethol among others, is a medication used for cancer and autoimmune diseases. Specifically it is used to treat acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn’s disease, and ulcerative colitis.

What are the side effects of the drug mercaptopurine?

Side Effects

• Black, tarry stools.
• clay colored stools.
• cough or hoarseness.
• decreased appetite.
• fever or chills.
• nausea, vomiting.
• pinpoint red spots on the skin.
• rash, itchy skin.

What is TPMT test results?

TPMT genetic test (genotype)—an alternative test to TPMT enzyme activity level is a genetic test that can identify genetic variations in the TPMT gene. This genetic test identifies individual genetic differences associated with risk for thiopurine toxicity. Each person has two copies of the TPMT gene.

Which is better azathioprine or mercaptopurine?

Azathioprine is generally the immunosuppressant of choice, but if azathioprine treatment fails, its active metabolite mercaptopurine may be tolerated. Mercaptopurine is unlicensed for inflammatory bowel disease but has been used for many years in treating this condition and is in line with national guidelines.