Can miRNA target non-coding RNAs?

Long non-coding RNAs can act as miRNA decoys by sequestering miRNAs, thus acting as competing endogenous RNAs and leading to re-expression of miRNA target genes [13, 102, 103].

What is the function of the lncRNA Hotair?

HOTAIR is an lncRNA that plays a role as an oncogenic molecule in different cancer cells, such as breast, gastric, colorectal, and cervical cancer cells. Therefore, HOTAIR expression level is a potential biomarker for diagnostic and therapeutic purposes in several cancers.

Where are Micrornas found?

While the majority of miRNAs are located within the cell, some miRNAs, commonly known as circulating miRNAs or extracellular miRNAs, have also been found in extracellular environment, including various biological fluids and cell culture media.

How does microRNA regulate gene expression?

How microRNA controls gene expression. microRNA controls gene expression mainly by binding with messenger RNA (mRNA) in the cell cytoplasm. Instead of being translated quickly into a protein, the marked mRNA will be either destroyed and its components recycled, or it will be preserved and translated later.

How do you target a lncRNA?

To target lncRNAs function several technologies namely, small molecules, nanobodies, aptamers, and RNA decoys have been proposed to disrupt interactions between lncRNA/protein via competition or steric blockade [53].

How does HOTAIR regulate gene expression?

HOTAIR has been shown to function as a key regulator of chromatin states and dynamics by binding to the specific chromatin modification complex polycomb repressive complex 2 (PRC2), thereby recruiting and affecting PRC2 occupancy on genes genome-wide [2, 3].

What is the function of the HOTAIR ncRNA quizlet?

How does HOTAIR exert its function? The protein component of telomerase has what enzymatic function? It makes an DNA polymer using RNA as a template. The sequence of a short ncRNA is 5′ AGCCCUAUGACGUU 3′.

How is microRNA made?

MicroRNAs are transcribed by RNA polymerases II and III, generating precursors that undergo a series of cleavage events to form mature microRNA. The conventional biogenesis pathway consists of two cleavage events, one nuclear and one cytoplasmic.