How do you dissolve penicillin G?

Add 3.6 mL of water for injection to the 600 mg vial to make a 150 mg/mL solution. Draw up 1 mL (150 mg of penicillin) of solution and add 4 mL of water for injection to make a final volume of 5mL with a concentration of 30 mg/mL solution.

Is penicillin G soluble in water?

Penicillin G is soluble in water, attains high concentrations in blood, and is excreted in urine in 4 to 6 hours. Penicillin G is available in crystalline, procaine, and benzathine forms. Because it is unstable at low pH, oral administration is not possible, so the agent is administered by injection.

What is the solubility of penicillin?

The “wonder drug” penicillin is actually a group of drugs that have different functional groups on one of the side chains on the bicyclic core….Benzylpenicillin acid. fast facts.

CAS Reg. No.	61-33-6
Appearance	White crystals or powder
Melting point	82–83 ºC
Water solubility	210 mg/L

How do you dilute benzathine penicillin?

Conclusion: Use of lidocaine hydrochloride as a diluent for benzathine penicillin G does not change the penicillin concentration in body fluids and significantly reduces the pain of injection. We suggest the use of lidocaine hydrochloride 1% as a diluent for benzathine penicillin G.

What is penicillin G procaine?

Penicillin G Procaine – Clinical Pharmacology. Penicillin G Procaine is an equimolecular compound of procaine and penicillin G, administered intramuscularly as a suspension. It dissolves slowly at the site of injection, giving a plateau type of blood level at about 4 hours which falls slowly over a period of the next 15 to 20 hours.

How do you administer penicillin G procaine?

Penicillin G Procaine (aqueous) is for intramuscular injection only. Administer by DEEP INTRAMUSCULAR INJECTION in the upper, outer quadrant of the buttock (dorsogluteal) or the anterolateral thigh (ventrogluteal). In neonates, infants and small children, the midlateral aspect of the thigh may be preferable.

What percentage of penicillin G is bound to serum protein?

Approximately 60% of penicillin G is bound to serum protein. The drug is distributed throughout the body tissues in widely varying amounts. Highest levels are found in the kidneys with lesser amounts in the liver, skin, and intestines.

What is the bactericidal activity of penicillin G?

The bactericidal activity of penicillin G results from the inhibition of cell wall synthesis and is mediated through penicillin G binding to penicillin binding proteins (PBPs). Penicillin G is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.