How should gentamicin be stored?
How should gentamicin be stored?
Sterile solutions of gentamicin sulfate should be stored at 2-8 °C. Solutions of gentamicin have been shown to be stable when stored at room temperature, and in boiling aqueous buffers of pH 2-14. 2 A solution at 1 mg/ml in 0.1 M potassium phosphate buffer (pH 8.0), stored at 2-8 °C, should be used within 30 days.
How long is gentamicin IV good for?
The serum half-life of gentamicin is approximately 2-3 hours in adults with normal renal function. It is prolonged in patients with impaired renal function and in premature or newborn infants.
What is the half-life of gentamicin?
Patients in whom gentamicin had a short half-life, patients with fever, and adults with a high extracellular fluid volume had low peak concentrations. The mean half-life after intravenous administration was 75 min (range, 26-230 min). The mean half-life was 29 min longer after intramuscular dosage (p less than 0.01).
How long is gentamicin stable for after reconstitution?
After dilution: when diluted with 0.9% sodium chloride or 5% glucose solution, gentamicin is stable for 24 h at 25°C. Chemical and physical in-use stability has been demonstrated for 24 hours at 25°C.
Does gentamicin need refrigeration?
We recommend that the Gentamicin be stored refrigerated at a temperature of 2-8 °C, protected from strong light exposure. Always use aseptic techniques when handling Gentamicin. This antibiotic solution is hazardous.
How do you make gentamicin solution?
Weigh 0.5 g of Gentamicin (Gentamicin (Sulfate), GoldBio Catalog # G-400 [CAS 1405-41-0, mw. = 477.6]). 2. Add 10 ml of sterile H2O.
Is gentamicin compatible with dextrose?
For adults, prepare IV infusions by diluting the calculated dose of gentamicin with 50–200 mL of 0.9% sodium chloride or 5% dextrose injection. ADD-Vantage vials should be diluted according to the manufacturer’s directions prior to IV infusion.
Does gentamicin need to be refrigerated?
What is the pH of gentamicin?
The pH is 4.5 (3.0 to 5.5).
Is gentamicin compatible with sodium chloride?
For intermittent intravenous administration in adults, a single dose of Gentamicin Sulfate in 0.9% Sodium Chloride Injection may be administered according to individual patient requirements from the appropriate premixed container.
Can gentamicin be frozen?
The results of the study indicated that minibag admixtures of carbenicillin disodium, cephalothin sodium, cloxacillin sodium, gentamicin sulfate, penicillin G potassium, erythromycin gluceptate, cefazolin sodium and rolitetracycline base in the concentrations tested can be frozen for 30 days without a significant loss …
Is gentamicin soluble in water?
Gentamicin Sulfate is suitable for use in cell culture to prevent and control bacterial contamination and the compound is soluble in water (50 mg/ml).
Is gentamicin water soluble?
How do you dissolve gentamicin sulfate?
Add 10 ml of sterile H2O. Dissolve completely.
Is gentamicin hydrophilic?
Gentamicin is a hydrophilic drug that is distributed to body water and excreted unchanged by the kidneys, predominantly by glomerular filtration.
Is gentamicin polar or nonpolar?
Gentamicin, vancomycin, and calcitonin are polar drugs that have poor oral availability. Gentamicin is a broad-spectrum aminoglycoside antibiotic (Mr 550) and vancomycin is a glycopeptide antibiotic that has important utility in fighting antibiotic-resistant Gram-positive bacterial infections (Mr 1,400).
How do you make gentamicin stock solution?
For a stock solution of 7.5 mg/mL:
- 150 mg Gentamicin.
- 20 mL ddH2O.
- Filter sterilize.
Is gentamicin lipophilic or hydrophilic?
Gentamicin is highly hydrophilic, i.e. not distributed into body fat and minimally distributed into tissue fluids.
Is gentamicin lipophilic?
Tobramycin and gentamicin are highly and moderately lipophilic (-LogP=5.8 and 3.1, respectively), but both distribute primarily in extracellular fluid, not adipose (Table 3).