What are ATM genes?

What are ATM genes?

The ATM gene provides instructions for making a protein that is located primarily in the nucleus of cells, where it helps control the rate at which cells grow and divide.

What protein does ATM code for?

The ATM gene codes for a 350 kDa protein consisting of 3056 amino acids. ATM belongs to the superfamily of phosphatidylinositol 3-kinase-related kinases (PIKKs). The PIKK superfamily comprises six Ser/Thr-protein kinases that show a sequence similarity to phosphatidylinositol 3-kinases (PI3Ks).

Is the ATM gene genetic?

Everyone has two copies of the ATM gene, which we randomly inherit from each of our parents. Mutations in one copy of the ATM gene can increase the chance for you to develop certain types of cancer in your lifetime.

Does everyone have ATM gene?

Does everyone have an ATM gene?

What do we know about the function of the ATM gene?

The identification of ATM , the gene responsible for the pleiotropic recessive disease ataxia telangiectasia, has initiated extensive research to determine the functions of its multifaceted protein product.

Is ATM a high-risk gene variant?

With the possible exception of the V2424G variant31, which might be considered a high-risk gene variant, ATMis considered to afford a moderate lifetime risk of breast cancer for which management is unclear39.

What is the prognosis of atmin ATM mutations in breast cancer?

ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects. Int J Radiat Oncol Biol Phys. 2002;52:606–13. doi: 10.1016/S0360-3016(01)02684-0. [PubMed] [CrossRef] [Google Scholar] 69. Fang Z, Kozlov S, McKay MJ, et al. Low levels of atmin breast cancer patients with clinical radiosensitivity.

Which ATM mutations cause ataxia–telangiectasia in breast cancer?

Renwick A, Thompson D, Seal S, et al. ATM mutations that cause ataxia–telangiectasia are breast cancer susceptibility alleles. Nat Genet. 2006;38:873–5. doi: 10.1038/ng1837.