What are the markers of hepatitis B?

Abstract. The serum markers of hepatitis B virus (HBV) infection are complex, mainly including HBV surface antigen (HBsAg) and antibody to HBsAg, HBV e antigen (HBeAg) and antibody to HBeAg, antibody to HBV core antigen.

What marker is the first to appear in HBV infection?

HBsAg (hepatitis B surface antigen) is the first serologic marker to appear in a new acute infection, which can be detected as early as 1 week and as late as 9 weeks, with an average of one month after exposure to the hepatitis B virus (HBV).

What is the lifelong marker for HBV infection?

Chronic HBV is diagnosed by the absence of IgM anti-HBc antibody. IgM anti-HBc antibody is a marker of acute or recent acute hepatitis B and is detectable for 6 months after infection, whereas IgG anti-HBc is lifelong.

What marker indicates immunity to hepatitis B infection?

Anti-HBs: Antibody to hepatitis B surface antigen is a marker of immunity. Its presence indicates an immune response to HBV infection, an immune response to vaccination, or the presence of passively acquired antibody.

What is the normal range of HBV viral load?

HBV: Hepatitis B virus. # Normal values: ALT: Males: 10-40 U/L; Females: 7 – 35 U/L; AST: Males: 15 – 40 U/L; Females: 13 – 35 U/L. HBeAg-positive patients had significantly higher ALT levels (mean 170.3 ± 391 IU/L) compared to HBeAg-negative patients (mean 53.9 ± 169.4 IU/L), p < 0.0001 (Table 2).

Is Australia an antigen?

“Australia antigen” is an antigen found in the sera of patients with acute and chronic hepatitis, and it may actually be a form of virus. It is very common in many tropical areas, and people in these areas having the antigen appear to be hepatitis carriers.

What is log10 HBV IU mL?

An “Undetected” result indicates that hepatitis B virus (HBV) DNA was not detected in the serum specimen. A result of “<10 IU/mL (<1.00 log IU/mL)” indicates that HBV DNA is detected, but the HBV DNA level present cannot be quantified accurately below this lower limit of quantification of this assay.

What are dominant and co dominant markers?

Codominant markers indicate differences in size whereas dominant markers are either present or absent. Strictly speaking, the different forms of a DNA marker (e.g. different sized bands on gels) are called marker ‘al- leles’.

Which hepatitis virus is also known as Australian antigen?

Hepatitis B surface antigen, HBsAg (‘Australian antigen’ component), characteristically appears in the serum of the majority of patients with acute hepatitis B during the first few days of the illness and tests to recognize this antigen are valuable diagnostically (Table 15.2).

Is hepatitis B common in Australia?

Hepatitis B is the most common blood borne virus (BBV) in Australia and a leading cause of primary liver cancer. 1 At the end of 2016, an estimated 237 894 people were living with chronic hepatitis B in Australia.

What is the normal range of HBV?

Normal range for this assay is Not Detected. The quantitative range of this assay is 1.00-9.00 log IU/mL (10-1,000,000,000 IU/mL).