What are the side effects of dofetilide?

Side Effects

• Chest pain.
• facial or flaccid paralysis.
• numbness or tingling of the hands, feet, or face.
• paralysis.
• pounding, slow heartbeat.
• slurred speech.
• swelling of the ankles, arms, face, feet, fingers, legs, lips, tongue, or throat.
• troubled breathing.

What happens if you stop taking Tikosyn?

Stopping suddenly may make your condition worse. Follow your doctor’s instructions about tapering your dose. Tell your doctor if you have a prolonged illness that causes severe diarrhea, vomiting, or heavy sweating. These conditions can cause an electrolyte imbalance, making it dangerous for you to use Tikosyn.

What medications should not be taken with Tikosyn?

The concomitant use of verapamil or the cation transport system inhibitors cimetidine, trimethoprim (alone or in combination with sulfamethoxazole), or ketoconazole with TIKOSYN is contraindicated (see WARNINGS and PRECAUTIONS, Drug-Drug Interactions), as each of these drugs cause a substantial increase in dofetilide …

Does dofetilide lower heart rate?

Dofetilide is used to correct irregular heartbeat of patients with atrial fibrillation or atrial flutter to a normal heart rhythm. Dofetilide belongs to the group of medicines known as antiarrhythmics. It works by slowing nerve impulses in the heart. This medicine is available only with your doctor’s prescription.

Is dofetilide a safe drug?

Dofetilide may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

Can dofetilide cause heart failure?

Our study demonstrates that long-term use of dofetilide, with the dose adjusted according to renal function, is not associated with an increased risk of death among patients with congestive heart failure and reduced left ventricular function.

Can you stop dofetilide?

Do not stop taking TIKOSYN until your doctor tells you to stop. If you miss a dose, just take the next dose at your regular time.

When should I stop taking Tikosyn?

To be specific, Tikosyn is used to convert (change) atrial flutter or AFib to a normal sinus rhythm. A normal sinus rhythm is a healthy heart rhythm. If you have AFib or atrial flutter, your heart doesn’t beat normally. You shouldn’t use Tikosyn if you have a heart rhythm disorder called paroxysmal atrial fibrillation.

Is Tikosyn a high risk medication?

As with other drugs that cause Torsade de Pointes, TIKOSYN was associated with a greater risk of Torsade de Pointes in female patients than in male patients. During the TIKOSYN clinical development program, the risk of Torsade de Pointes in females was approximately 3 times the risk in males.

Can dofetilide cause weight loss?

No clinically relevant direct effects of dofetilide on serum electrolytes were observed in clinical studies and there have been no published reports of anorexia or weight loss directly related to dofetilide use.

Is dofetilide safe?

Dofetilide is safe and effective in preventing atrial fibrillation recurrences in patients accepted for catheter ablation.

When should I stop taking dofetilide?

Dofetilide was discontinued if QTc persisted for >500 ms after dose reduction or if the patient developed VT. Serum electrolytes, including potassium and magnesium, were monitored daily during the hospital stay and corrected as needed.

How long does dofetilide stay in your system?

Tikosyn has a half-life of roughly ten hours, which means it takes that long for your body to clear it from your system.

Can Tikosyn cause death?

Tikosyn should be used only if your AFib or atrial flutter is causing serious symptoms, such as heart palpitations, chest pain, and shortness of breath. This is because Tikosyn may cause serious changes in your heart rhythm that, in rare cases, can be fatal.

Does dofetilide cause weight loss?

How many doses of dofetilide can you miss?

What happens if I skip more than one dose? Do not miss more than one dose. If you miss more than one dose, you must stop taking the medication and let your doctor know. You will most likely be readmitted to the hospital to restart the medication, just as you Page 2 did the first time.

Is Tikosyn a good drug?

Effectiveness for maintaining normal sinus rhythm in AFib and atrial flutter. In clinical trials, Tikosyn was an effective medication to maintain sinus rhythm in people with AFib or atrial flutter. In the studies, people took Tikosyn or a placebo (treatment with no active drug) twice a day.