What are the types of transplant rejection?

There are three types of rejection:

• Hyperacute rejection occurs a few minutes after the transplant when the antigens are completely unmatched.
• Acute rejection may occur any time from the first week after the transplant to 3 months afterward.
• Chronic rejection can take place over many years.

What is Status 7 on heart transplant list?

Status 7 or inactive list: Inactive due to a change in condition – patients do not lose time they have already accrued.

Is transplant rejection a Type 2 hypersensitivity?

Acute Transplant Rejection is the most common type of rejection and usually has an onset between weeks and months of the transplant. It is a T-Cell mediated response against foreign Major Histocompatibility Complex in the donated organ. Therefore, it is an example of Type IV hypersensitivity.

What is status 2 on heart transplant list?

If you are listed Status 1 or Status 2, you are considered to be in the most urgent need of a heart transplant. You will be considered before patients with Status 3 through Status 6 for heart offers from a much wider geographic area than under the current system — up to 500 miles from the donor’s location.

What is status 1A for heart transplant?

Status 1A are individuals who must stay in the hospital as in-patients and require high doses of intravenous drugs, require a ventricular assist device (VAD) for survival, are dependent on a ventilator or have a life expectancy of a week or less without a transplant.

What is humoral rejection?

Humoral rejection (antibody-mediated or hyperacute rejection) is rare after liver transplantation, developing in patients with pre-formed antibodies or subsequently formed antibodies to a donor liver that is incompatible with ABO blood groups.

What is chronic rejection?

Chronic rejection (CR) is an immune phenomenon characterized by vasculopathy (intimal hyperplasia, perivasculitis obliterative endarteritis of graft vessels), fibrosis, and atrophy of graft with progressive loss of function that culminates in graft loss.

What does 1B mean on a transplant list?

Individuals classified as Status 1B are generally not required to stay in the hospital as in-patients. These individuals may require a VAD or low doses of continuous intravenous medications. Individuals classified as Status 1B have the second highest priority on the heart transplant, wait list.

What are the 4 major types of grafts?

There are four classifications of grafts: (1) autograft (tissue removed from one site and surgically implanted into another on the same individual); (2) isograft (tissue removed from an individual and surgically grafted onto a genetically identical individual, such as an identical twin or another member of the same …

What type of hypersensitivity is transplant rejection?

Transplant

Transplant Rejection
Rejection Type	Pathogenesis
Chronic	Type II and IV hypersensitivity reaction secondary to CD4+ T-cells responding to the host’s antigen presenting cells