What does Pdgfra mean?

The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a family of proteins called receptor tyrosine kinases (RTKs).

What is D842V mutation?

The most frequent mutation is the substitution at position 842 in the A-loop of an aspartic acid (D) with a valine (V) in exon 18, widely recognized as D842V. This mutation, as well known, provides primary resistance to imatinib and sunitinib.

What is Pdgfra mutation?

A gene that makes a protein that is involved in cell division and cell survival. Mutated (changed) forms of the PDGFRA gene and protein have been found in some types of cancer, including gastrointestinal stromal tumors and chronic eosinophilic leukemia. These changes may increase the growth of cancer cells.

How long does imatinib take to work?

Using RECIST, the median time to response is approximately 3 months, and median time to disease progression on imatinib is about 2 years.

What is gastric GIST?

A gastrointestinal stromal tumor (GIST) is a type of cancer that begins in the digestive system. GIST s happen most often in the stomach and small intestine. A GIST is a growth of cells that’s thought to form from a special type of nerve cells.

When is the best time to take imatinib?

It is usually taken with a meal and a large glass of water once or twice a day. Take imatinib at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take imatinib exactly as directed.

What happens if I stop taking imatinib?

A total of 61% of patients lost undetectable minimal residual disease at a median of 2.5 months after discontinuation of imatinib for CML; no recurrences occurred after 22 months.

What kind of test is FIP1L1 PDGFRA?

FIP1L1-PDGFRA is an abnormal fusion gene sequence that causes the bone marrow to produce too many eosinophils, a type of white blood cell. It is a rare cause of hypereosinophilia (HE) and hypereosinophilic syndrome (HES). This test detects the FIP1L1-PDGFRA gene sequence to help diagnose these conditions.

What cancers does imatinib treat?

Imatinib is used to treat certain types of leukemia (cancer that begins in the white blood cells) and other cancers and disorders of the blood cells.

Can imatinib cause kidney damage?

Conclusion. The introduction of imatinib therapy in nonclinical trial CML patients is associated with potentially irreversible acute renal injury, and the long-term treatment may cause a clinically relevant decrease in the estimated GFR.

Is imatinib a chemotherapy drug?

Imatinib, sold under the brand names Gleevec and Glivec (both marketed worldwide by Novartis) among others, is an oral chemotherapy medication used to treat cancer.

What is PDGFRA test?

To identify mutations in platelet-derived growth factor receptor alpha (PDGFRA) gene seen in a subset of gastrointestinal stromal tumors (GIST) which can help confirm the diagnosis of GIST and are useful for therapeutic planning.

Can eosinophilic leukemia be cured?

Treatments. Chronic eosinophilic leukemia is rare and can develop differently in different people. It can be stable for many years and then quickly change into AML. As a result, there is no standard treatment plan for chronic eosinophilic leukemia.