What does the CYP17 gene do?

Normal Function. The CYP17A1 gene provides instructions for making a member of the cytochrome P450 enzyme family. Like other cytochrome P450 enzymes, CYP17A1 is involved in the formation (synthesis) of steroid hormones.

What is a CYP17 inhibitor?

A CYP17A1 inhibitor is a type of drug which inhibits the enzyme CYP17A1. It may inhibit both of the functions of the enzyme, 17α-hydroxylase and 17,20-lyase, or may be selective for inhibition of one of these two functions (generally 17,20-lyase).

Why are CYP17 inhibitors effective for prostate cancer?

Background and Aims: CYP17 inhibitors can block androgen production both intratumorally and systemically, thus attenuating the progression of prostate cancer (PCa).

What does abiraterone therapy do?

Abiraterone is used in combination with prednisone to treat a certain type of prostate cancer that has spread to other parts of the body. Abiraterone is in a class of medications called androgen biosynthesis inhibitors. It works by decreasing the amount of certain hormones in the body.

Does bicalutamide inhibit CYP17 pathway?

However, it has been reported that bicalutamide has weak affinity for the progesterone receptor (PR), where it is an antagonist, and hence it could have some antiprogestogenic activity. Bicalutamide does not inhibit 5α-reductase nor is known to inhibit other enzymes involved in androgen steroidogenesis (e.g., CYP17A1).

Which CYP17 inhibitor decreases Extragonadal production of androgens in patients with prostate cancer?

Hence, the extragonadal ablation of androgen synthesis from pregnane precursors holds much promise. An inhibitor of cytochrome P450 17α−hydroxy/17,20-lyase (CYP17) enzymes, abiraterone acetate, has already been approved for men with mCRPC.

Is bicalutamide better tolerated than flutamide?

Conclusions: In patients with metastatic prostate cancer, bicalutamide plus LHRH-A is well tolerated and provides superior efficacy to flutamide plus LHRH-A with respect to time to treatment failure.

What is the function of 17 alpha hydroxylase?

The enzyme has 17 alpha(α)-hydroxylase activity, which is important for production of glucocorticoids and sex hormones. CYP17A1 also has 17,20-lyase activity, which is integral to the production of sex hormones. 17α-hydroxylase/17,20-lyase deficiency results from a shortage (deficiency) of both enzyme activities.

What are side effects of abiraterone?

Side Effects

• Bladder pain.
• bloating or swelling of the face, arms, hands, lower legs, or feet.
• bloody or cloudy urine.
• bone pain or fracture.
• chest pain or discomfort.
• decreased urine.
• difficult, burning, or painful urination.
• fast, pounding, or irregular heartbeat or pulse.

What is the difference between bicalutamide and Apalutamide?

Apalutamide binds AR in the same ligand-binding domain as bicalutamide but with greater affinity, and unlike bicalutamide, retains full antagonist activity in the setting of AR overexpression (48). Furthermore, apalutamide was shown to be selective for AR over other nuclear hormone receptors (48).