What is a Phosphomonoesterase?

What is a Phosphomonoesterase?

Phosphoric monoester hydrolases (or phosphomonoesterases) are enzymes that catalyse the hydrolysis of O-P bonds by nucleophilic attack of phosphorus by cysteine residues or coordinated metal ions. They are categorized with the EC number 3.1. 3. Examples include: acid phosphatase.

Is phosphatase a hydrolase?

In biochemistry, a phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases.

Which cell organelle is rich in acid phosphatase?

The role of axonal lysosomes, the transport organelles containing acid phosphatase, and the relationship between these and the degradation of endocytotic structures are discussed by Holtzman (1977).

What is phosphatase used for?

A phosphatase is an enzyme that removes a phosphate group from a protein. Together, these two families of enzymes act to modulate the activities of the proteins in a cell, often in response to external stimuli.

What is the purpose of acid phosphatase?

Acid phosphatase (ACP, EC number 3.1. 3.2) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment, hence its name.

What does high acid phosphatase mean?

Acid phosphatase: An enzyme that acts to liberate phosphate under acidic conditions and is made in the liver, spleen, bone marrow, and prostate gland. Abnormally high serum levels of acid phosphatase may indicate infection, injury, or cancer of the prostate.

What causes high acid phosphatase?

Prostatic acid phosphatase (PAP), which is produced in the prostate, was the first major serum marker for prostate cancer. Metastasis of prostate cancer beyond the capsule, particularly to the bone, causes a rise in acid phosphatase level, with the level increasing in correspondence to the extent of the disease.

What does acid phosphatase test for?

Acid phosphatase testing is done to diagnose whether prostate cancer has spread to other parts of the body (metastasized), and to check the effectiveness of treatment. The test has been largely supplanted by the prostate specific antigen test (PSA).

What does acid phosphatase do in the body?

Function. Acid phosphatase (ACP, EC number 3.1. 3.2) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid.