What is CSP in malaria?

What is CSP in malaria?

Circumsporozoite protein (CSP) is a secreted protein of the sporozoite stage of the malaria parasite (Plasmodium sp.) and is the antigenic target of RTS,S, a pre-erythrocytic malaria vaccine currently undergoing clinical trials.

What does circumsporozoite protein do?

Circumsporozoite protein (CSP) is the dominant protein on the surface of Plasmodium sporozoites and plays a critical role in the invasion by sporozoites of hepatocytes.

What are Hypnozoites?

Hypnozoites are dormant forms in the life cycles of certain parasitic protozoa that belong to the Phylum Apicomplexa (Sporozoa) and are best known for their probable association with latency and relapse in human malarial infections caused by Plasmodium ovale and P. vivax.

Is circumsporozoite protein an antigen?

The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites. Nature. 2006 Dec 14;444(7121):937-40.

How do you cite PlasmoDB?

We suggest that PlasmoDB be referenced as follows: The Plasmodium Genome Consortium (2001) PlasmoDB: an integrative database of the Plasmodium falciparum genome. Tools for accessing and analyzing finished and unfinished sequence data. Nucleic Acids Res., 29, 66–69.

What is cysteine string protein?

Cysteine string protein (CSP) is a member of the DnaJ/Hsp40 family of co-chaperones that localises to neuronal synaptic vesicles. Its name derives from the possession of a string of 12–15 cysteine residues, palmitoylation of which is required for targeting to post-Golgi membranes.

What supergroup is plasmodium in?

Plasmodium is a member of the phylum Apicomplexa, a large group of parasitic eukaryotes. Within Apicomplexa, Plasmodium is in the order Haemosporida and family Plasmodiidae….

Family: Plasmodiidae
Genus: Plasmodium Marchiafava & Celli, 1885

Can a 5 month old baby have malaria?

Burden of malaria in infants aged less than six months Various studies across Africa have demonstrated that 7–10% of newborns may have malaria parasites in their cord blood [8], in some cases either without evidence of an active maternal infection or with parasite genotypes different to those found in the mother.