What is CYP24A1 gene?

CYP24A1 (Cytochrome P450 Family 24 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP24A1 include Hypercalcemia, Infantile, 1 and Idiopathic Infantile Hypercalcemia. Among its related pathways are Metabolism of steroids and Oxidation by cytochrome P450.

What is vitamin D metabolism?

The metabolism of vitamin D. The liver converts vitamin D to 25OHD. The kidney converts 25OHD to 1,25(OH)2D and 24,25(OH)2D. Other tissues contain these enzymes, but the liver is the main source for 25-hydroxylation, and the kidney is the main source for 1α-hydroxylation.

What hormone influences the activation of vitamin D at the kidneys to 1 25 Dihydroxycholecalciferol?

Control of Vitamin D Synthesis The major inducer of 1-alpha-hydroxylase is parathyroid hormone; it is also induced by low blood levels of phosphate.

What does the cytochrome P450 gene do?

Cytochrome P450 monooxygenases catalyze the oxidation and metabolism of a large number of xenobiotics and endogenous compounds. CYP450 enzymes evolved as the primary defense against xenobiotics and in this process are also responsible for the bioactivation of drugs and toxicants to more reactive intermediates.

What is the difference between 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D?

Serum levels of 25-hydroxyvitamin D (25(OH)D) are used to establish an individual’s vitamin D status, while the biologically active molecule, 1,25-dihydroxyvitamin D (1,25(OH)2D), is produced by the hydroxylation of 25(OH)D primarily in the kidneys under the regulation of parathyroid hormone (PTH) and serum calcium [3] …

What does a high vitamin D 1 25 dihydroxy mean?

A high level of 1,25-dihydroxyvitamin D may occur when there is an excess parathyroid hormone or when there are diseases, such as sarcoidosis or some lymphomas, that can make 1,25-dihydroxyvitamin D outside of the kidneys.

What is the purpose of CYP?

Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and homeostasis. Induction or inhibition of CYP enzymes is a major mechanism that underlies drug-drug interactions.

What does it mean if vitamin D 1 25 dihydroxy is high?

What is a normal vitamin D 1 25 dihydroxy?

Reference ranges for 1,25(OH)2 D are as follows : Males: 18-64 pg/mL. Females: 18-78 pg/mL.