What is deferasirox used for?

What is deferasirox used for?

Deferasirox is used to remove excess iron from the body in patients who have had too many blood transfusions and in patients with non-transfusion dependent thalassemia syndromes. Deferasirox is an iron chelator (binder). It combines with iron in the blood.

How do you administer deferasirox?

Administration. Do not chew tablets or swallow them whole. Take Exjade once daily on an empty stomach at least 30 minutes before food, preferably at the same time each day. Completely disperse tablets by stirring in water, orange juice, or apple juice until a fine suspension is obtained.

Who makes deferasirox?

EAST HANOVER, N.J., January 23, 2013 /PRNewswire/ — Novartis announced today that the US Food and Drug Administration (FDA) has approved Exjade® (deferasirox) for the treatment of chronic iron overload in patients 10 years of age and older with non-transfusion-dependent thalassemia (NTDT) syndromes and with a liver …

Can deferasirox be crushed?

Advertising revenue supports our not-for-profit mission. Swallow tablets whole with water or other liquids. If you have trouble swallowing the whole tablet, it may be crushed and mixed with soft foods (eg, apple sauce or yogurt) immediately before taking it orally.

Is there generic deferasirox?

Officials with the FDA have granted final approval to Glenmark Pharmaceuticals’ Deferasirox Tablets for Oral Suspension, 125 mg, 250 mg and 500 mg. The drug is the generic version of Exjade® (deferasirox, Novartis) Tablets for Oral Suspension, 125 mg, 250 mg and 500 mg.

How much does Exjade cost?

Deferasirox (Exjade) costs $60 – $158 per day versus $26 – $112 per day for deferoxamine.

What is the brand name for deferasirox?


Clinical data
Trade names Exjade, Jadenu
Other names CGP-72670, ICL-670A, IC L670
AHFS/Drugs.com Monograph
License data EU EMA: by INN US DailyMed: Deferasirox

What happens if your iron is too high?

Excessive iron can be damaging to the gastrointestinal system. Symptoms of iron toxicity include nausea, vomiting, diarrhea and stomach pain. Over time, iron can accumulate in the organs, and cause fatal damage to the liver or brain.

Why deferasirox is taken empty stomach?

The approved mode of administration requires taking deferasirox on an empty stomach with water, apple juice, or orange juice to limit variation in bioavailability. This required administration schedule might not be palatable for patients.