What is extranodal marginal zone lymphoma?

This page is about MALT lymphoma (also known as extranodal marginal zone lymphoma). This is a slow-growing type of non-Hodgkin lymphoma. It most commonly develops in the stomach (when it is called gastric MALT lymphoma) but it can develop in other parts of the body (which is called non-gastric MALT lymphoma).

Is extranodal marginal zone lymphoma curable?

pylori eradication in cases where reinfection occurs. Otherwise alternative therapy is appropriate. Patients with other subtypes of nodal and extranodal marginal zone lymphoma are at high risk for relapse following initial therapy (advanced stage disease is rarely, if ever, curable).

What does marginal zone mean?

Marginal zone lymphomas are types of slow-growing (low-grade) non-Hodgkin lymphomas that develop from B cells. They are called marginal zone lymphomas because they develop in a particular region found at the edge of normal lymphoid tissues (collections of lymphocytes) called the marginal zone.

What are the stages of marginal zone lymphoma?

Staging of Marginal Zone Lymphoma (MZL)

Nodal MZL Stage	Description1
Stage III	MZL involves: Nodes on both sides of the diaphragm Nodes above the diaphragm with spleen involvement
Stage IV	MZL is in its most advanced stage, with: Additional non-contiguous extranodal involvement

What is Extralymphatic organ?

Extralymphatic means other than lymph nodes and other lymphatic structures. These lymphatic structures include spleen, thymus gland, Waldeyer’s ring (tonsils), Peyer’s patches (ileum) and lymphoid nodules in the appendix.

What are the symptoms of marginal zone lymphoma?

You may also have symptoms specific to the type of lymphoma. For example, people with MALT may experience: indigestion. stomach pain….Symptoms associated with all forms of the disease include:

• fever without an infection.
• night sweats.
• unexplained weight loss.
• skin rash.
• chest or abdominal pain.
• tiredness.

What are extranodal sites in lymphoma?

The term extranodal disease refers to lymphomatous infiltration of anatomic sites other than the lymph nodes. Almost any organ can be affected by lymphoma, with the most common extranodal sites of involvement being the stomach, spleen, Waldeyer ring, central nervous system, lung, bone, and skin.

Why is lymphoma called marginal zone?

What does extranodal spread mean?

Extranodal extension refers to the growth of a nodal cancer metastasis beyond the confines of the capsule of a lymph node into adjacent tissues. Less preferred synonyms include extranodal spread, extracapsular extension, or extracapsular spread. This finding holds prognostic implications.

Can marginal zone lymphoma spread?

As with other types of MZL, it tends to grow and spread slowly, and treatment may be safely delayed unless symptoms or other problems arise. Nodal marginal zone lymphoma is much more rare. It starts within lymph nodes and doesn’t often spread beyond them, and it’s usually slow-growing.