What is KatG in TB?

Mycobacterium tuberculosis catalase-peroxidase (KatG) is a bifunctional hemoprotein that has been shown to activate isoniazid (INH), a pro-drug that is integral to frontline antituberculosis treatments.

What does KatG gene do?

KatG is an enzyme that functions as both catalase and peroxidase. Its mutation is the cause for Mycobacterium (specifically M. tuberculosis) resistance with the drug isoniazid, which targets the mycolic acids within the tuberculosis bacteria.

What is mycobacterial catalase peroxidase?

The Mycobacterium tuberculosis catalase-peroxidase is a multifunctional heme-dependent enzyme that activates the core anti-tuberculosis drug isoniazid.

Who should not use isoniazid?

You should not use isoniazid if you are allergic to it, or if you have: active liver disease; a history of severe allergic reaction to isoniazid; a history of hepatitis or other liver problems caused by taking isoniazid; or.

What is mycolic acid synthesis?

Biosynthesis of mycolic acid precursors requires two types of fatty acid synthases (FASs), the eukaryotic-like multifunctional enzyme FAS I and the acyl carrier protein (ACP)-dependent FAS II systems, which consists of a series of discrete mono-functional proteins, each catalyzing one reaction in the pathway.

Is Mycobacterium catalase positive?

Mycobacteria are Gram-positive, catalase positive, non-motile, non-spore forming rod-shaped bacteria (0.2–0.6 μm wide and 1.0–10 μm long). The colony morphology of mycobacteria varies with some species growing as rough or smooth colonies.

Is TB catalase positive?

tuberculosis and other tubercle bacilli. Catalase converts hydrogen peroxide to water and oxygen, generating oxygen bubbles in a liquid solution. Virtually all mycobacteria except certain isoniazid-resistant tubercle bacilli are catalase-positive.

Why do you take vitamin B6 with isoniazid?

Vitamin B6 (pyridoxine) supplementation during isoniazid (INH) therapy is necessary in some patients to prevent the development of peripheral neuropathy.