What is meant by progressive multifocal leukoencephalopathy?

What is meant by progressive multifocal leukoencephalopathy?

Definition. Progressive multifocal leukoencephalopathy (PML) is a disease of the white matter of the brain, caused by a virus infection that targets cells that make myelin–the material that insulates nerve cells (neurons).

What causes progressive multifocal leukoencephalopathy?

Progressive multifocal leukoencephalopathy is a rare infection of the brain that is caused by the JC (John Cunningham) virus. People with a weakened immune system are most likely to get the disorder. People may become clumsy, have trouble speaking, and become partially blind, and mental function declines rapidly.

What virus causes progressive multifocal leukoencephalopathy?

What causes progressive multifocal leukoencephalopathy (PML)? PML occurs because of the JC virus (JCV) — named after the initials of the first patient identified with it. Up to 85% of all adults have the JC virus.

What is the meaning of PML?

Progressive multifocal leukoencephalopathy (PML) is a rare infection that damages the material (myelin) that covers and protects nerves in the white matter of the brain.

What does leukoencephalopathy mean?

Leukoencephalopathy with vanishing white matter is a progressive disorder that mainly affects the brain and spinal cord (central nervous system). This disorder causes deterioration of the central nervous system’s white matter, which consists of nerve fibers covered by myelin.

What happens when you have PML?

Progressive multifocal leukoencephalopathy (PML) is a disease that attacks part of your brain. It happens if your body can’t fight off disease the way it should. It damages your brain’s white matter — cells that make a substance called myelin.

What are the symptoms of leukoencephalopathy?


  • Clumsiness or loss of coordination.
  • Difficulty walking.
  • Facial drooping.
  • Loss of vision.
  • Personality changes.
  • Trouble speaking.
  • Weak muscles.

What is white matter vs GREY matter?

Gray matter largely functions to receive information and regulate outgoing information, as it contains the cell bodies of neurons. White matter, which is largely composed of axons, serves to transmit signals to other regions of the brain, spinal cord, and body.

Can COVID cause fluid on the brain?

Researchers at the University of California San Francisco found abnormalities in the cerebrospinal fluid — the clear, colorless liquid that’s found in the brain and spinal cord — of 10 of 13 people who were infected with COVID and had thinking problems.

Can COVID give you MS?

Indeed, some studies show that viral respiratory tract infections may be linked to most of the exacerbations of MS (Marrodan et al., 2019). If we focus on the coronavirus (CoV) family, there is clear evidence of its neurotropic character.

Can you grow back grey matter?

As long as the neuron cell bodies remain healthy, axons can regrow and slowly repair themselves. Functional recovery may also occur if the information can be transmitted through an alternative route. In many cases, this occurs through the strengthening of weak connections that already exist.

When does smell return after COVID?

Most of the time, when you lose your sense of smell, it’s because the virus has attacked these support cells. When these support cells regenerate (on average four to six weeks later; for some it takes longer) your sense of smell will return.”

Why do you lose taste and smell with COVID?

Researchers are still trying to determine how and why the COVID-19 virus affects smell and taste. One study suggests the virus doesn’t directly damage olfactory sensory neurons. Instead, it may affect cells that support these neurons. Once the infection goes away, the olfactory nerve starts working properly again.

Are tomatoes good for MS?

According to Harvard Women’s Health Watch, an anti-inflammatory diet should include foods like tomatoes, leafy greens such as spinach and kale, and fruits like strawberries, blueberries, cherries, and oranges. There’s some evidence that consuming these foods could be beneficial for MS.

What is grey matter disease?

Gray matter disease Diseases that cause the loss of the neurons that make up gray matter are primarily called neurodegenerative diseases. These diseases, which include dementias like Alzheimer’s disease and frontotemporal dementia, affect millions of people worldwide.