What is rhBMP?

rhBMP-2 is the active agent in INFUSE Bone Graft. rhBMP-2 is a disulfide-linked dimeric protein molecule with two major subunit species of 114 and 131 amino acids. Each subunit is glycosylated at one site with high-mannose-type glycans. rhBMP-2 is produced by a genetically engineered Chinese hamster ovary cell line.

What is BMP infuse?

An Infuse Bone Graft consists of two parts: A genetically engineered form of a natural protein (bone morphogenetic protein, or BMP) found in the human body that helps regulate bone growth and healing.

What is infuse used for?

Infuse has been on the market since 2002 and has been used in more than 1 million patients worldwide. Infuse is indicated for certain spinal fusion procedures in skeletally mature patients with degenerative disc disease (DDD) from L2 to S1, as well as for treating certain acute, open tibial shaft fractures.

What is Medtronic Infuse bone graft?

InfuseTM Bone Graft contains a manufactured bone graft material that is approved for use as a bone graft in sinus augmentation and localized alveolar ridge augmentation. It provides an alternative to bone-harvest surgery, a secondary procedure which can be painful for some patients and lengthens the healing process.

Is bone morphogenetic protein Safe?

Types of BMPs Although 20 different BMPs have been discovered, only BMP-2 is currently FDA approved and available in recombinant form for use in human spine surgery. BMP-7, or OP-1, was previously given a Humanitarian Device Exemption and ultimately was not approved by the FDA.

How much does bone morphogenetic protein cost?

The upfront price of bone morphogenetic protein (3380 dollars) is likely to be offset to a significant extent by reductions in the use of other medical resources, particularly if costs incurred during the 2 year period following the index hospitalization are taken into account.

Is BMP FDA approved?

Although 20 different BMPs have been discovered, only BMP-2 is currently FDA approved and available in recombinant form for use in human spine surgery. BMP-7, or OP-1, was previously given a Humanitarian Device Exemption and ultimately was not approved by the FDA.

Why is Osteoconductivity important in a bone graft?

Osteoconduction is the ability of bone-forming cells in the grafting area to move across a scaffold and slowly replace it with new bone over time. Osteoconductive materials serve as a scaffold onto which bone cells (osteoblasts and osteoclasts) can attach, migrate, grow and/or divide.

How much does infuse cost?

Infuse Pro is $. 99/month, $9.99/yearly, or $74.99/lifetime. With a Pro upgrade, you’ll unlock more file formats, AirPlay support, 24-bit Dolby TrueHD and DTS-HD MA audio, streaming from cloud services, and all future features in version 8, 9, 10, and beyond.

Is Infuse bone graft safe?

The Infuse Bone Graft appears to be safe for use in lower back, or lumbar, surgery, however the procedure has been used in fusions involving the cervical spine, or vertebrae of the neck which may have resulted in complications.

What is infuse in spinal surgery?

INFUSE (bone morphogenetic protein-2) stimulates bone growth in the space between vertebrae. It is used in place of the patient’s own bone in spinal fusion surgery. In 2002, the U.S. Food and Drug Administration (FDA) approved INFUSE for only one type of spine surgery: anterior approach lumbar interbody fusion (ALIF).

Where does bone morphogenetic protein come from?

Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in extracts derived from bone, are now known to play important roles in a wide array of processes during formation and maintenance of various organs including bone, cartilage, muscle, kidney, and blood vessels.

What is bone morphogenetic protein made of?

Bone morphogenetic proteins (BMPs), glycoproteins secreted by some cells, are members of the TGF-β superfamily that have been implicated in a wide variety of roles. Currently, about 20 different BMPs have been identified and grouped into subfamilies, according to similarities with respect to their amino acid sequences.

How is BMP administered?

The BMPs are eluted through a purified collagen matrix which is implanted in the site of the fracture. rhBMP-2 helps grow bone better than any other rhBMP so it is much more widely used clinically.

What is the function of Osteoconductivity?

They provide the structural support for osteogenic cells and can regulate cell behavior, including proliferation, differentiation, and migration, resulting in the formation of regenerated functional tissues [144,145].

What is Augment bone graft?

Augment® Bone Graft is a combination device/drug product being developed for use in bone repair and regenerative procedures. Augment® Bone Graft is indicated for use as an alternative to autograft in arthrodesis (i.e., fusion procedures) of the ankle and/or hindfoot indicating the need for supplemental graft material.

What is Infuse bone?

Infuse™ Bone Graft is the premium product for autograft replacement* due to its high osteoinductivity. Infuse bone graft is recombinant human bone morphogenetic protein-2 (rhBMP-2) applied to an absorbable collagen sponge carrier (ACS). One of the functions of the protein is to stimulate natural bone formation.