What is the function of CREB?

CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element.

What is a CREB inhibitor?

CREB is a transcription factor implicated in the pathogenesis of multiple cancers. Targeting CREB is a promising strategy to develop potential cancer therapeutics. Previously, we identified 666-15 as a potent CREB inhibitor.

How can I increase my CREB?

Maintaining healthy eating, exercise, and sleeping patterns is key to the production and activation of CREB protein. Supplements like cinnamon, blueberry extract, and butyrate can also boost your CREB protein levels.

Does phosphorylation affect the nuclear localization of CREB?

CREB activity is regulated by the phosphorylation of amino acid (aa) residues, which are mainly localized in the KID region, thereby influencing the dimerization of CREB and its binding to the CRE sequence [5].

Is CREB a neurotransmitter?

CREB is not a neurotransmitter but a cellular transcription factor, which binds to DNA sequences called cAMP response elements, thereby increasing or decreasing the transcription of downstream genes (Bourtchuladze et al., 1994).

What is CREB phosphorylation?

CREB is phosphorylated on Ser133 by PKA (protein kinase A), promoting the recruitment of the co-activator proteins CBP (CREB-binding protein) and p300; this has been proposed to increase the transcription of CREB-dependent genes.

What is CREB psychology?

CREB (cAMP response element binding) is a protein that is a transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE) and thereby increases or decreases the transcription, and thus the expression, of certain genes.

When is CREB phosphorylated?

What is the function of CREB in long term memory?

The cellular transcription factor CREB (cAMP response element-binding protein) helps learning and the stabilization and retrieval of fear-based, long-term memories. This is done mainly through its expression in the hippocampus and the amygdala.

What type of gene regulation is CREB?

The CREB is one of the major regulators of neurotrophin responses since phosphorylated CREB binds to a specific sequence in the promoter of BDNF and regulates its transcription. Moreover, susceptibility genes associated with schizophrenia also target and stimulate the activity of CREB.