What is the function of lactate dehydrogenase?
What is the function of lactate dehydrogenase?
Lactate dehydrogenase (LDH) is an important enzyme of the anaerobic metabolic pathway. It belongs to the class of oxidoreductases, with an enzyme commission number EC 1.1. 1.27. The function of the enzyme is to catalyze the reversible conversion of lactate to pyruvate with the reduction of NAD+ to NADH and vice versa.
What does a high lactate dehydrogenase level mean?
Higher than normal LDH levels usually means you have some type of tissue damage or disease. Disorders that cause high LDH levels include: Anemia. Kidney disease. Liver disease.
What is the difference between lactate and lactate dehydrogenase?
The key difference between lactate and lactate dehydrogenase is that lactate is the deprotonated form of lactic acid, whereas lactate dehydrogenase is an enzyme that is important in converting lactate into pyruvate.
What does a low LD level mean?
Body fluids: Cerebrospinal fluid—a high LD indicates that meningitis is likely caused by bacteria, while a low or normal level indicates viral meningitis is more likely. A high LD indicates that pericardial fluid, peritoneal or pleural fluid is an exudate, while a low level indicates it is transudate.
Is LDHA tumor marker?
LDH as a diagnostic and prognostic marker for cancers However, more recent studies have shown that LDH is a non-specific diagnostic marker for cancers [23, 54, 58].
What drugs cause high LDH?
Drugs that can increase LDH measurements include:
- Anesthetics.
- Aspirin.
- Colchicine.
- Clofibrate.
- Cocaine.
- Fluorides.
- Mithramycin.
- Narcotics.
How is high lactate dehydrogenase treated?
Large amounts of vitamin C (ascorbic acid) may lower LDH levels. Alcohol, anesthetics, aspirin, narcotics, and procainamide may raise LDH levels. Strenuous exercise may also raise LDH levels. Ask your doctor about any medications you should avoid before the test.