What is the hydrolysis of aspirin?

Hydrolysis of Aspirin. Aspirin, also known as acetylsalicylic acid, has an ester functional group. Just like esters, aspirin can undergo hydrolysis under acidic conditions or basic conditions.

What is the active ingredient in aspirin?

The technical name of the active ingredient in aspirin is acetylsalicylic acid. When it reacts with water, we end up with two products, salicylic acid and acetic acid. This is a fairly slow reaction unless it’s also heated.

What is the reaction between aspirin and salicylic acid?

As one aspirin (acetyl salicylic acid) molecule is hydrolyzed, one salicylic acid molecule is formed, reflected in the hydrolysis reaction. Also, as the environment in which the aspirin hydrolysis reaction is occurring becomes more basic, both the rate of reaction of the hydrolysis of aspirin and also the formation of salicylic acid increase.

What is the Hammett Reaction constant for aspirin hydrolysis?

acetate ion of the hydrolysis of aspirin. The reaction Jencks). (1961). tate22). The Hammett reaction constant, VI. 11. represents general base catalysis.

What is the role of bchelocus in plasma aspirin hydrolase activity?

The BCHElocus is a major (but not the sole) determinant of plasma aspirin hydrolase activity. A, as shown by the Q-Q plot from the GWAS analyses, the obtained pvalues deviate from those expected by chance, suggesting that a subset of these signals reflect true associations.

Does aspirin hydrolysis alter platelet sensitivity to inhibition?

The rate of aspirin hydrolysis varied widely among donors, primarily from epigenetic BChE variation, and was sufficient to alter platelet sensitivity to aspirin inhibition. EXPERIMENTAL PROCEDURES Materials

Is aspirin dispersed monomolecularly in the mixture with PCC?

As aspirin molecules would be adsorbed onto the pore surface of PCC in the molecular state, as a possible mechanism of aspirin hydrolysis in the mixture with PCC it was suggested that the aspirin is dispersed monomolecularly in the heated mixture and reacts with water molecules rather than by acid-base catalysis. [Pg.788]