What is UniProtKB in bioinformatics?

The UniProt Knowledgebase (UniProtKB) is an expertly curated database, a central access point for integrated protein information with cross-references to multiple sources. The UniProt Archive (UniParc) is a comprehensive sequence repository, reflecting the history of all protein sequences (1).

What are the differences between UniProtKB Swiss-Prot and UniProtKB TrEMBL?

UniProtKB/Swiss-Prot is manually curated which means that the information in each entry is annotated and reviewed by a curator, while the records in UniProtKB/TrEMBL are automatically generated and are enriched with automatic annotation and classification.

How UniProtKB database is useful in identifying the function of a protein?

The UniProt database has cross-references to over 150 databases and acts as a central hub to organize protein information. Its accession numbers are a primary mechanism for accurate and sustainable tagging of proteins in informatics applications.

Why is UniProtKB composed of 2 sections?

The centrepiece of the UniProt databases is the UniProt knowledge base (UniProtKB), which comprises 2 sections: manually annotated UniProtKB/Swiss-Prot and automatically annotated UniProtKB/TrEMBL. Taken together, these 2 sections give access to all publicly available protein sequences.

What is UniProtKB Swiss-Prot what is its purpose?

Its main goal is to provide the scientific community with a central resource for protein sequences and functional information. The UniProt consortium maintains the UniProt KnowledgeBase (UniProtKB) and several supplementary databases including the UniProt Reference Clusters (UniRef) and the UniProt Archive (UniParc).

Why does UniProtKB have two parts?

These UniProtKB/TrEMBL unreviewed entries are kept separated from the UniProtKB/Swiss-Prot manually reviewed entries so that the high quality data of the latter is not diluted in any way. Automatic processing of the data enables the records to be made available to the public quickly.

Is SWISS-PROT a secondary database?

Complete answer: SWISS PROT is a protein sequence database. Annotations in the database provide all the information regarding the structure and function of a particular protein along with its functions and modifications if any. The data is all primary and easily accessible.

Is PDB a secondary database?

PDB (Berman et al., 2000) is the most comprehensive repository of structure data for biological macromolecules. The repository contains the primary structure and secondary structure information along with the atomic coordinates of a constituent atoms of biomolecule.

Why do we need UniProt?

UniProt helps with this in the following ways: It provides an up-to-date, comprehensive body of protein information at a single site. It aids scientific discovery by collecting, interpreting and organising this information so that it is easy to access and use.

Who created Swiss Prot?

SWISS-PROT (1) is an annotated protein sequence database, which was created at the Department of Medical Biochemistry of the University of Geneva and has been a collaborative effort of the Department and the European Molecular Biology Laboratory (EMBL), since 1987.

How do I access SWISS-PROT database?

There are multiple sites on the Web that can access the Swiss-Prot/TrEMBL and retrieve the database. Its main sites are the ExPASy Molecular Biology website (http://www.expasy.org/) and the European Institute of Bioinformatics (EBI) website (http://www.ebi.ac.uk/swissprot/).

What is Swissport database?

SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases.