Which conditions are adverse effects of sodium-glucose cotransporter 2 inhibitors?

Some of the adverse effects can be predicted from the mechanisms of action of the SGLT2 inhibitors.

• Genitourinary infections. SGLT2 inhibitors are associated with 3–5-fold increased risk of fungal genital infections (such as candidiasis).
• Volume depletion.
• Ketoacidosis.
• Amputations.
• Fractures.
• Acute kidney injury.

Why do SGLT2 cause ketoacidosis?

SGLT2 inhibitors may be associated with ketoacidosis due to their ketogenic effects secondary to enhanced lipolysis and hyperglucagonaemia and this could pose a problem in the presence of other contributory factors for ketoacidosis.

Can you have DKA without high blood sugar?

In most cases, ketoacidosis in people with diabetes will be accompanied by high sugar levels. However, ketoacidosis can also occur at low or normal blood glucose levels.

What is the most common adverse effect seen with SGLT2 inhibitors?

The most common side effects of SGLT2 inhibitors include genital yeast infections, flu-like symptoms and a sudden urge to urinate. The U.S. Food and Drug Administration also warns of more rare but serious issues such as amputations, kidney injury and ketoacidosis.

When should SGLT2 inhibitors be discontinued?

The changes recommend temporary discontinuation of SGLT2 inhibitors before scheduled surgery due to the greater risk of patients developing ketoacidosis. According to the updated label: Canagliflozin, dapagliflozin, and empagliflozin should each be discontinued at least 3 days before scheduled surgery.

Are warning letters public?

Warning letters are made public. Anyone can find that the company has been issued a letter. We’ve even heard of competitors using a company’s warning letter as a negative example of why a potential customer should choose their own company over the competing one.

Why does Jardiance cause DKA?

Jardiance causes your body to make more ketones. A buildup of ketones in the body can cause the blood to be too acidic. Symptoms of ketoacidosis can include: high blood sugar levels.

Is DKA life threatening?

Diabetic ketoacidosis (DKA) is life-threatening—learn the warning signs to be prepared for any situation. DKA is no joke, it’s a serious condition that can lead to diabetic coma or even death. DKA is caused by an overload of ketones present in your blood.

Who should not take SGLT2 inhibitors?

Who Shouldn’t Take an SGLT2 Inhibitor? The FDA hasn’t approved these medications to treat type 1 diabetes. They’re not recommended for anyone who has had diabetic ketoacidosis, a serious complication of diabetes. SGLT2 inhibitors also aren’t that helpful for someone who already has severe kidney disease.

When should SGLT2 inhibitors not be used?

(9) SGLT2 inhibitors are contraindicated for patients with renal insufficiency (GFR < 45 mL/min/1.73m2). However, they may be very useful without regard to diabetes duration because their action is independent of β-cell function and insulin secretion.

What are the most common side effects of SGLT2 inhibitors?