Why is glucose low in CSF in meningitis?

The reason for the reduced glucose levels associated with bacterial meningitis was believed to be the need for glucose as fuel by infiltrating immune cells in response to infection. However, the possibility that the bacteria itself could manipulate glucose concentrations in the brain had not been explored before now.

What causes increase and decrease in CSF glucose levels?

Chemical meningitis, inflammatory conditions, subarachnoid hemorrhage, and hypoglycemia also cause hypoglycorrhachia (low glucose level in CSF). Elevated levels of glucose in the blood is the only cause of having an elevated CSF glucose level.

Should there be glucose in CSF?

Normal Results The glucose level in the CSF should be 50 to 80 mg/100 mL (or greater than 2/3 of the blood sugar level).

What does high protein and low glucose in CSF mean?

High CSF protein concentration may prognosticate for a poor outcome in neonates with bacterial meningitis [4]. High CSF protein and low CSF glucose have been associated with increased risk of sensorineural hearing loss in bacterial meningitis [5, 6].

Is glucose high or low in bacterial meningitis?

In bacterial meningitis, the CSF glucose level (reference range, 40-70 mg/dL) is less than 40 mg/dL in 60% of patients. A simultaneous blood glucose determination should be obtained for the purposes of comparison.

What is the relationship between blood glucose levels and CSF glucose in an individual?

The glucose level in CSF is proportional to the blood glucose level and corresponds to 60-70% of the concentration in blood. Therefore, normal CSF glucose levels lie between 2.5 and 4.4 mmol/L (45–80 mg/dL).

How do you interpret glucose in CSF?

Normal levels of glucose in the CSF are greater than 50 mg/dL to 80 mg/dL, or 2.8 mmol/L to 4.4 mmol/L. If your levels are lower, you may have an infection. Your healthcare provider will look at your CSF glucose level along with the other CSF tests, and possibly other tests, to better understand what your results mean.

What is normal glucose level in CSF?

Normal Results The glucose level in the CSF should be 50 to 80 mg/100 mL (or greater than 2/3 of the blood sugar level). Note: Normal value ranges may vary slightly among different laboratories. Talk to your health care provider about the meaning of your specific test results.

What is the normal glucose level of cerebrospinal fluid CSF?

Why is glucose measured in CSF?

Why Is a CSF Glucose Test Done? The CSF glucose test can be useful when checking for spinal cord or brain infections such as meningitis, because people with these infections have low glucose in their cerebrospinal fluid. Your doctor may order this test if you show these symptoms: Nausea.

What does CSF glucose indicate?

A CSF glucose test measures the amount of sugar (glucose) in the cerebrospinal fluid (CSF). CSF is a clear fluid that flows in the space surrounding the spinal cord and brain. A lumbar puncture, or spinal tap, is a procedure to collect cerebrospinal fluid to check for the presence of disease or injury.

What does low CSF protein mean?

Low levels of protein in your CSF could mean your body is leaking cerebrospinal fluid. This could be due to a traumatic injury such as head or spine trauma.

What is the normal CSF glucose level?

What does high glucose in CSF indicate?

In addition, damage to small blood vessels during lumbar puncture (traumatic tap) can lead to an increased CSF glucose since the blood that enters the collected CSF sample contains higher levels of glucose.

What causes low protein in CSF?

What is the relationship between CSF glucose and lactate?

Our study demonstrates that in clinically relevant levels of hyperglycemia (i.e. plasma glucose 7.8–25 mmol/L), CSF glucose is linearly correlated with plasma glucose. The reference range for CSF lactate is generally set at 1.2–2.1 mmol/L, but ranges from 0.6 to 3.1 mmol/L are used as well (Table 2) [1].

What does a high glucose level in CSF mean?

Glucose levels in CSF are compared with blood plasma levels of glucose. CSF protein concentration. Increases may mean brain or spinal cord disease. CSF leukocyte, or white blood cell, count. It’s usually high if you have an infection.

What causes low CSF glucose?

Infections, especially bacterial infections, and tumors are the most common causes of low CSF glucose levels. Cells that aren’t usually present in your CSF, such as bacteria, cells produced by tumors, or white blood cells present to fight inflammation, can metabolize, or digest, the glucose.

What does glucose in CSF indicate?

A CSF glucose test checks the amount of sugar (glucose) in your cerebrospinal fluid (CSF), a clear liquid that surrounds the spinal cord and brain. The test can detect infections of the brain or spinal cord.