Which is better denosumab or zoledronic acid?

Which is better denosumab or zoledronic acid?

Denosumab and zoledronic acid are both bone-modifying agents that prevent the occurrence of SREs. Denosumab has been shown to be superior to zoledronic acid in delaying SREs in various types of cancer, such as breast cancer, lung cancer, and multiple myeloma.

Is denosumab better than bisphosphonates?

Denosumab was superior to bisphosphonates for increasing bone mineral density (BMD), and possibly for reducing fracture risk, in patients with osteoporosis or low BMD, according to a report published in the Journal of Clinical Endocrinology & Metabolism.

What is the best infusion for osteoporosis?

Zoledronic acid (ZOL) is an intravenous bisphosphonate that is given once yearly for the treatment of osteoporosis via a medically supervised 15-minute infusion. This ensures compliance for a full 12 months.

What is the gold standard treatment for osteoporosis?

Bisphosphonates (BPs) are the pioneer and gold standard drugs for osteoporosis treatment. The development of BPs started decades ago. There are four bisphosphonates in the osteoporosis market: alendronate, risedronate, ibandronate, and zolendronate.

Is there an alternative to zoledronic acid?

Risedronate (oral) Bisphosphonates can also be given as tablets; these are slightly less effective than an infusion of zoledronic acid, at reducing bone remodelling, and the effect doesn’t last quite as long. The most commonly used oral treatment is 30mg of risedronate sodium, taken daily, for two months.

Is zoledronic acid the same as Prolia?

Are Reclast and Prolia the Same Thing? Reclast (zoledronic acid) and Prolia (denosumab) are drugs used to treat or prevent osteoporosis in postmenopausal women. The drugs are in different drug classes. Reclast is a bisphosphonate and Prolia is a monoclonal antibody.

Is Reclast or Prolia better?

In a small study with 107 participants, people who received Prolia and those who got Reclast saw similar improvements in their bone mineral density (BMD), a measure of bone health. A larger study compared the drugs to each other, focusing primarily on the risk of serious infections, heart disease, or bone fractures.

What is the best medication for severe osteoporosis?

Bisphosphonates are usually the first choice for osteoporosis treatment. These include: Alendronate (Fosamax), a weekly pill. Risedronate (Actonel), a weekly or monthly pill.